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joint_support_formula_90.jpgJoint Support Formula $30.00

DESCRIPTION:

Three part combination formula designed to provide both a nutritional foundation for long term joint health as well as acute joint problems

FORMULA:

Three tablets provide:

PRIMARY CONNECTIVE TISSUE BUILDING BLOCK

Glucosamine Sulfate....................... 1,500. mg

    (potassium complex from 2001 mg natural shellfish extract)

 

BOTANICAL COMPLEX TO FIGHT INFLAMMATION

Boswellia Leaf and Stem (Boswellia serrata) a   450   mg

Bromelainb......................................... 300. mg

Bioflavonoid Complex....................... 600. mg

Turmeric Rhizome (Curcuma longa) c 120         mg

Yucca Branch and Trunk (Yucca schidigera)    75      mg

Ginger Rhizome (Zingiber officinale) 75. mg

Quercetin............................................. 30. mg

VITAMIN/MINERAL SUPPORT

Vitamin C (ascorbic acid)................. 180. mg

Niacinamide........................................ 150. mg

Manganese (sulfate)............................... 5. mg

Zinc (L-OptiZinc® zinc monomethionine) d       3       mg

Copper (gluconate)........................... 0.15. mg

(a.) Standardized for a guaranteed potency of 60% boswellic acid. (b.) Enteric coated. (c.) Standardized for a guaranteed potency of 95% curcumins. (d.) OptiZinc® is a trademark of InterHealth N.I.

KEY FEATURES:

·        Unique, 3-part formula provides a blend of glucosamine (primary building block of joint and connective tissue), a synergistic botanical complex with vitamins & minerals involved with the maintenance and repair of joint and connective tissues.

·        Contains glucosamine sulfate (extracted from shellfish), the form shown highly effective and most utilized in clinical studies.  Glucosamine sulfate is a building block of the much larger chondroitin molecule.

·        Provides the sodium-free, potassium complex of glucosamine sulfate for added electrolyte support.

·        High potency, full spectrum formula, manufactured under strict quality control guidelines in our regulated, federally registered, pharmaceutical manufacturing facility.

·        ADVANCED HERBAL DELIVERY SYSTEM® processing provides a superior product compared to typical herbals. Where appropriate, botanical ingredients are present as highly concentrated extracts for optimum digestion and utilization.

·        Free of corn, soy, yeast, wheat, egg and milk products.

DIRECTIONS:

One to three tablets per day (take between meals). If patient is very sensitive, may be taken with food. Store in a cool, dry place away from children.

HOW SUPPLIED:

Dark gold caplet-shaped tablet; 30 or 90 per bottle.

BACKGROUND:

·        Glucosamine is a primary component of connective (especially chondroitin) joint tissue structures and fluids. Recent scientific and medical studies have confirmed the important role this substance plays in joint tissue treatments[1] and effectiveness within pain management has been reported equaling a common drug[2].

·        In our botanical complex we provide: bromelain; a natural enzyme complex from pineapple containing at least three unique cysteine proteases. This complex is effective at reducing swelling and inflammation around damaged sites[3], by impeding platelet aggregation and initiating fibrinolysis.  By performing these roles, bromelain increases the blood flow to the injured tissues, and this helps return tissues to normal; highly concentrated standardized extracts containing boswellia, turmeric, ginger, and quercitin. These plants have been used for centuries as traditional medicines in India and China. Extracts from boswellia[4], turmeric[5] and ginger[6] exhibit properties for fighting inflammation primarily by reducing expression of the cathepsins (metalloproteinases) which catalyze tissue structure degradation and by reducing the effects of tissue necrosis factor (TNF), a key contributor to programmed cell senescence.

·        We also provide vitamin C, niacinamide, manganese, copper, and zinc monomethionine (OptiZinc®); all nutrients essential for rapid recovery of joint and connective tissues. Vitamin C is a cofactor and the three metals are components at the active sites of enzymes producing collagen, cartilage, synovial fluid and other key components of connective tissues. For instance, vitamin C plays a well-defined role in the enzymatic synthesis of hydroxyproline within pre-formed collagen; this, along with other biochemical reactions, results in transformation of collagen from a filamentous, but elastic substance into a highly woven network with strength in all directions.  A necessity for keeping bones and joints in alignment.



[1] Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulfate.  S. Christgau, et al., Clinical Experimental Rheumatology 22: 36-42 (2004).  The effect of glucosamine supplementation on people experiencing regular knee pain.  R. Braham, B. Dawson and C. Goodman British Journal Sports Medicine 37: 45-49 (2003).

[2] Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. H. Müller-Fassbender et al., Osteoarthritis Cartilage 2: 61-69 (1994).

[3] Bromelain and its clinical application. An update. S.J. Taussig and S. Batkin,  J. Ethnopharmacology, 22:191 (1988).

[4] Regulation of vascular response to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to anti-inflammatory boswellia. S. Roy et al., Antioxidant and Redox Signaling 8: 653-660 (2006).

[5] Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).  N. Cainani-Wu, Journal of Alternative and Complementary Medicine 9: 161-168 (2003).

[6] Ginger extract components suppress induction of chemokine expression in human synoviocytes.  P.V. Phan, et al., Journal of Alternative and Complementary Medicine 11: 149-154 (2005). Suppressive effects of mioga ginger constituents on reactive oxygen and nitrogen species generation and the expression of inducible pro-inflammatory genes in macrophages.  H.W. Kim, et al., Antioxidant and Redox Signaling 7: 1621-1629 (2005).